Psoriasi e rischi correlati

Un recente studio condotto dal gruppo di ricerca di Joel Gelfand, professore associato di dermatologia presso l’Università della Pennsylvania, dimostra che le persone affette da psoriasi sono esposte ad un maggiore rischio di malattie. La psoriasi, infatti, si associa frequentemente a malattie polmonari croniche, diabete mellito, infarto del miocardio, ulcera gastrica, malattie reumatologiche e vascolari. Gli autori, inoltre, evidenziano come la gravità della malattia psoriasica si associ ad un maggior rischio di presentare tali comorbidità. In particolare, i soggetti affetti da forme di psoriasi che colpiscono più del 10% della superficie della pelle sono esposti ad un rischio di malattie cardiache e dei vasi sanguigni due volte maggiore rispetto alle persone non affette.

Qui in seguito proponiamo l’abstract in lingua originale dell’articolo scientifico consultabile qui.

Buona lettura dal laboratorio di analisi e poliambulatorio Polo Biomedico Adriatico

 

JAMA Dermatol. 2013 Aug 7. doi: 10.1001/jamadermatol.2013.5015. [Epub ahead of print]

Psoriasis Severity and the Prevalence of Major Medical Comorbidity: A Population-Based Study.

Yeung H, Takeshita J, Mehta NN, Kimmel SE, Ogdie A, Margolis DJ, Shin DB, Attor R, Troxel AB, Gelfand JM.

Source

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Abstract

IMPORTANCE Despite the growing literature on comorbidity risks in psoriasis, there remains a critical knowledge gap on the degree to which objectively measured psoriasis severity may affect the prevalence of major medical comorbidity. OBJECTIVE To examine the prevalence of major medical comorbidity in patients with mild, moderate, or severe psoriasis, classified objectively based on body surface area involvement, compared with that in patients without psoriasis. DESIGN, SETTING, AND PARTICIPANTS Population-based cross-sectional study of patient data fromUnited Kingdom-based electronic medical records; analysis included9035 patients aged 25 to 64 years with psoriasis and 90350 age- and practice-matched patients without psoriasis. MAIN OUTCOMES AND MEASURES Prevalence of major medical comorbidity included in the Charlson comorbidity index. RESULTS Among patients with psoriasis, 51.8%, 35.8%, and 12.4%, respectively, had mild, moderate, or severe disease based on body surface area criteria. The mean Charlson comorbidity index was increasingly higher in patients with mild (0.375 vs 0.347), moderate (0.398 vs 0.342), or severe psoriasis (0.450 vs 0.348) (each P<.05). Psoriasis overall was associated with higher prevalence of chronic pulmonary disease (adjusted odds ratio, 1.08; 95% CI, 1.02-1.15), diabetes mellitus (1.22; 1.11-1.35), diabetes with systemic complications (1.34; 1.11-1.62), mild liver disease (1.41; 1.12-1.76), myocardial infarction (1.34; 1.07-1.69), peptic ulcer disease (1.27; 1.03-1.58), peripheral vascular disease (1.38; 1.07-1.77), renal disease (1.28; 1.11-1.48), and rheumatologic disease (2.04; 1.71-2.42). Trend analysis revealed significant associations between psoriasis severity and each of the above comorbid diseases (each P<.05). CONCLUSIONS AND RELEVANCE The burdens of overall medical comorbidity and of specific comorbid diseases increase with increasing disease severity among patients with psoriasis. Physicians should be aware of these associations in providing comprehensive care to patients with psoriasis, especially those presenting with more severe disease.


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